Experimental use of oral propolis for prevention of radiation oesophagitis in patients treated with chest radiotherapy

publication date: Jun 25, 2010
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Journal of ApiProduct
& ApiMedical Science
                                            
Vol. 2 (3) pp. 100 - 101
DOI
Date
July 2010
 
Article Title

 
Experimental use of oral propolis for prevention of radiation oesophagitis in patients treated with chest radiotherapy


Author(s)

 
F Meroni, R. Alloni, M. Ciresa, A. Scrocca1 and L. Trodella

Abstract
Oesophagitis is a common occurrence in patients subjected to chemoradiotherapy (CCRT) for lung cancer; exposure of a part of oesophagus to radiation can not be avoided despite careful planning of the treatment. Acute radiation injury of the oesophageal mucosa occurs within 3-4 weeks of treatment and dosimetric factors are predictive of acute oesophageal toxicity; concurrent chemotherapy and radiotherapy improve survival but increase toxicity, which is mainly severe odynophagia, dysphagia and chest pain. Severe symptoms are frequently reported and difficult to relieve. A temporary or definitive discontinuation in therapeutic plan is mandatory for many patients. Propolis is a bee product which has been used as a folk medicine and it has been reported to possess various biological activities, mainly anti-inflammatory and antioxidative properties. We tested a propolis mixture (Cadigroup Laboratory, Rome, Italy) to evaluate its tolerability as a medication useful to prevent and/or treat swallowing symptoms; our endpoint is to allow patients to carry out their scheduled RT without symptoms.
Keywords

Radiation esophagitis, Radiotherapy for lung cancer, Propolis

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