Effect of Jungle honey on the chemotactic activity

publication date: Oct 1, 2010
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Journal of ApiProduct
& ApiMedical Science
                                            
Vol. 2 (4) pp. 149 - 154
DOI
10.3896/IBRA.4.02.4.03
 
Date
October 2010
 
Article Title

 
Effect of Jungle honey on the chemotactic activity of neutrophils


Author(s)

 
Mayuko Miyagawa, Miki Fukuda, Yuriko Hirono, Ayaka Kawazoe, Eri Shigeyoshi, Masaaki Sakura, Toru Takeuchi, Osamu Mazda, Kent E. Pinkerton and Minoru Takeuchi

Abstract
It is generally known that honey has antibacterial activity, yet there is no evidence concerning its chemotactic activity for neutrophils associated with bacterial infection. Jungle honey is collected from timber and blossom by wild honey bees that live in the tropical forest of Nigeria and it is used as a traditional medicine for bacterial infection, colds and skin inflammation. However, the effect of Jungle honey on neutrophil function is not clearly known. In this study, we investigated whether jungle honey induced the chemotactic activity of neutrophils from guinea pigs. The number of migrated neutrophils exposed to jungle honey was significantly increased compared with control. Furthermore, the radian and velocity as indicators of chemotactic activity of migrated neutrophils were significantly (p<0.001) increased at concentrations of 1 and 10 mg/mL Jungle honey compared to control. These results suggest that enhancement of chemotactic activity in neutrophils by Jungle honey may be contribute to preventing bacterial infection.
Keywords

neutrophil, chemotactic activity, radian, velocity, Jungle honey

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