Fine mapping identifies significantly associating markers for resistance to the honey bee brood fungal disease, Chalkbrood

publication date: Jun 6, 2013
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Journal of Apicultural Research
Vol. 52 (3) pp. 134-140
DOI
10.3896/IBRA.1.52.3.04
Date
July 2013
Article Title

Fine mapping identifies significantly associating markers for resistance to the honey bee brood fungal disease, Chalkbrood

Author(s)
Beth Holloway, Matthew R Tarver and Thomas E Rinderer
Abstract

Chalkbrood infection of honey bee (Apis mellifera) brood by the fungus Ascosphaera apis results in fatal encapsulation of susceptible larvae with a mycelial coat. Recent QTL analysis indicates that some level of physiological resistance exists in individual larvae. We performed a fine mapping analysis to define the genetic interval that confers resistance in the larvae and identify the strongest association molecular markers that could by useful for marker assisted selection of the trait. Evaluation of the interval suggests that only two possible genes (single Ig IL-related receptor-like, XM_003251514.1 and juvenile hormone-binding protein, XM_391872.4) are likely to be responsible for the resistance. Both genes are strong physiological candidates and potentially function as modulators of the antifungal-specific innate immunity pathway in insects.

Keywords
honey bee, chalkbrood, MAS, marker-assisted selection, fine mapping, Toll pathway, immunity, Apis mellifera, Ascosphaera apis
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