Is honey a plausible candidate for the prevention of in-stent restenosis?

publication date: Oct 1, 2011
Send a summary of this page to someone via email.
Journal of ApiProduct
& ApiMedical Science
                                            
Vol. 3 (4) pp. 160 - 163
DOI
10.3896/IBRA.4.03.4.02
 
Date
October 2011
 
Article Title

Is honey a plausible candidate for the prevention of in-stent restenosis?


Author(s)

Saravana Kumar Jaganathan, Vijayalakshmi Raman, Eko Supriyanto

Abstract

Coronary artery disease (CAD) is the major cause of death worldwide. Initially balloon angioplasty (BA) seemed to be a commonly available treatment for such disease. The major limitation of this method is restenosis. With the advancement of coronary stenting, the incidence rate of restenosis after ballon angioplasty has been greatly reduced. However, in-stent restenosis (accounting for 10- 40% of patients: mainly due to neointimal proliferation) has been a major drawback for such coronary interventions. To overcome this, drug eluting stents (DES) have  evolved as a prospective proposal. Stents coated with various anti-inflammatory, anti-migratory or anti-proliferative agents are under investigation. These additives suppress the inflammatory response, smooth muscle cell migration and proliferation, thereby inhibiting in-stent restenosis. In this context, it is proposed that honey with diverse polyphenolic and flavonoid composition may prevent in-stent restenosis. Recent research demonstrated that crude honey could exert an anti-proliferative effect against various cancer cell lines such as colon, breast, bladder, oral squamous cell carcinoma and osteosarcoma. Flavonoids and phenolic compounds present in honey have been attributed individually for their anti-inflammatory and anti-proliferative potential and it has been shown that usage of honey in wound healing reduces inflammation and pain. Therefore, we hypothesize that crude honey which is rich in flavonoid and phenolic compounds may be a potential agent in preventing the in-stent restenosis. If our hypothesis is proven correct, honey will be a valuable candidate for saving millions of lives  by preventing in-stent restenosis.

Keywords

Stent, Re-stenosis, Honey, Coronary artery disease, Drug eluting stents (DES)

Free pdf
 pdf